I'm having recurring nightmares about spreadsheets. Endless, boring, soul-killing spreadsheets. I don't need a psychiatrist to know what that's about.
Do you want to drive a creative and conscientious person to despair? Give her a lot of spreadsheets. I mean, a lot of them. Make sure that some of them only she will ever look at - that they serve no purpose whatsoever - and then require her to keep them up to date.
Next, some spreadsheets should never add up because you have not given your creative and conscientious person the correct data. Change her data to correspond with the numbers she is not allowed to know. Berate her for the spreadsheets not adding up. Repeat.
Of course you, gentle readers, would never want to drive anyone to despair because that is not what nice people do. But I think it's going to be a while before I stop jumping like a cat on hot bricks every time I see the Excel icon on my computer desktop.